The Girls' Club is a private association that a group of female creatures in the Ugly Americans universe have organized. It holds regular meetings where the girls talk about problems involved in their lives, such as the time Callie Maggotbone told others Mark Lilly got close to another girl.
- Callie Maggotbone
- Crocodile lady
- The old white-hair woman first seen in a meeting in the Department of Integration in "Demon Baby"
- Twayne Boneraper, even though he's a guy