After having intimacy issues the prior night, Callie goes baby-crazy after Mark starts fostering a demon orphan. Twayne starts to notice some odd changes in his body and tries to push Callie into a marriage in order to adopt the child.
While staying with Randall's parents in New Jersey, Mark accidentally "outs" his roommate as a zombie; Leonard tries to identify a strange blob creature who proves to be difficult to place in the workforce.
Mark meets a pair of treetures who are expected to participate in a public mating ritual sanctioned by New York City as a festival. Meanwhile, a molting Callie demands the kinkiest kind of sex out of Mark. And Randall loses his penis after visiting a movie theater.
Mark's new student is a woman who wants to become a vampire like her boyfriend. Grimes and his crew have to take anger management training under Leonard. Meanwhile, the people of the city are being afflicted by a strange illness called "Mad Larry Disease".
After further budget cuts threaten to shut down his program, Mark struggles to find a job for a giant ape. Meanwhile, Callie tries to resist her sudden attraction towards Twayne during a convention. And Randall loses the lower half of his body.