Karen is a strange unspecified creature with loose gray skin, small limbs, a huge head and a huge body.
Randall calls her after finding out he has lost his penis. When he asks her if he left anything at her place, she replies, "Nope just a big sweaty pile of me!" Randall then hangs up on her.
- Judging by the pictures on her walls, she likes cats, elephants and Blake.