He claims to have once been the leader of a massive hive dedicated to the propagation of his species (though Mark notes that his file says he's from Toronto), but now works as a house cleaner, using his body, or brain, as a sponge.
- Great Brain's appearance is modeled after the monsters in the 1958 movie Fiend Without a Face, which was in turn adapted from the 1930 story "The Thought-Monster" by Amelia Reynolds Long. The difference between Great Brain and the movie monster is that the movie monster has tendrils and a pair of eye stalks.
- Randall hints that Great Brain is scared of heights, in "Mummy Dearest".
Great Brain appears in nearly every episode in the series. The episodes listed below are where he plays a more active role in the story.
|Series and Games||Ugly Americans ‧ 5 On ‧ FUGLY | Citizen Ugly ‧ Apocalypsegeddon|
|Characters||Main||Mark Lilly ‧ Randall Skeffington ‧ Callie Maggotbone ‧ Leonard Powers ‧ Twayne Boneraper ‧ Francis Grimes|
|Recurring|| Aldermach Maggotbone ‧ Rosie ‧ Melchior ‧ Goon squad |
Mark's class : Croatian Man ‧ Doug ‧ Erik ‧ Great Brain ‧ Martin ‧ Toby
|Matt Oberg ‧ Kurt Metzger ‧ Natasha Leggero ‧ Randy Pearlstein ‧ M.L. Wooley ‧ Larry Murphy ‧ Julie Klausner ‧ Devin Clark ‧ Pete Holmes ‧ Mike O'Gorman|
|Writers||Devin Clark (creator) ‧ David M. Stern (development) ‧ Daniel Powell (exec. producer) ‧ Greg White ‧ Bill Krebs ‧ Jeff Poliquin ‧ Aaron Blitzstein ‧ Nate Federman ‧ Kevin Shinick|
|Directors||Devin Clark ‧ Aaron Augenblick (supervising producer) ‧ Richard Ferguson-Hull|
|Species (list)||Demon ‧ Human ‧ Manbird ‧ Succubus ‧ Vampire ‧ Wizard ‧ Zombie|
|Other categories||Episodes (list) | Government ‧ Items ‧ Locations ‧ Magic ‧ Media|