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The Abscess Hollywood hosts, as the title implies, are the two hosts of the television show Abscess Hollywood. One of them is a human brunette woman and the other one is an ass head man who has an ass for his head and speaks with the anus. Their show Abscess Hollywood reports on news about Hollywood celebrity and entertainment, which is a spoof on the show Access Hollywood in the real world.

They are first seen in the episode "Kill, Mark... Kill!" where they report on a story between Jessica Alba and zombie Abraham Lincoln.

Later in "Fools for Love", they host the game show Megaballs.

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